Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 2/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TAS1R3 | Q7RTX0 | 6/20 | 0.45 |
| ▸ | TAS1R1 | Q7RTX1 | 6/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8257877 | 1.00 | CTSB (0.46) | CTSBCTSLCTSSCTSKSMN1; SMN2 | |
| SCHEMBL5870333 | 0.87 | SMN1; SMN2 (0.50) | CTSBCTSLCTSSCTSKSMN1; SMN2 | |
| SCHEMBL3957174 | 0.81 | ALDH1A1 (0.49) | CTSKTAS1R3TAS1R1ALDH1A1LMNA | |
| SCHEMBL3957176 | 0.81 | ALDH1A1 (0.49) | CTSKTAS1R3TAS1R1ALDH1A1LMNA | |
| SCHEMBL6348182 | 0.80 | DPP4 (0.47) | CTSBCTSLCTSSCTSKSMN1; SMN2 | |
| SCHEMBL5869355 | 0.80 | DPP4 (0.47) | CTSBCTSLCTSSCTSKSMN1; SMN2 | |
| SCHEMBL2329487 | 0.77 | KMT2A (0.54) | SMN1; SMN2L3MBTL1MAPTKMT2ANPC1 | |
| SCHEMBL18775044 | 0.76 | MMP1 (0.47) | CTSBCTSLCTSSCTSKALDH1A1 | |
| SCHEMBL12009779 | 0.76 | KMT2A (0.53) | SMN1; SMN2L3MBTL1MAPTKMT2ANPC1 | |
| SCHEMBL12018733 | 0.76 | DPP4 (0.44) | CTSBCTSLCTSSCTSKSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6632830-B1 | Blood pressure related disease or disorder, cell proliferation disorder, kidney disorder, kinetensin associated disorder, inflammation associated disorder, or an allergic disorder | MILLENNIUM PHARMACEUTICALS, INC. | 2003-10-14 | — | — | US | disclosed |