Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 6/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 5/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.33 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7221648 | 0.86 | JAK2 (0.40) | ALDH1A1RAB9ACSNK1DCSNK1EJAK1 | |
| SCHEMBL6834309 | 0.80 | LMNA (0.42) | HPGDSMN1; SMN2HSD17B10ALDH1A1HTT | |
| SCHEMBL7216813 | 0.78 | F10 (0.39) | RAB9ANPC1 | |
| SCHEMBL7216626 | 0.77 | APLNR (0.44) | HPGDSMN1; SMN2HTTRAB9ANPC1 | |
| SCHEMBL6834487 | 0.75 | GAA (0.43) | SMN1; SMN2ALDH1A1HTTRAB9ANPC1 | |
| SCHEMBL7217055 | 0.75 | NPC1 (0.48) | TSHRSMN1; SMN2HTTRAB9ANPC1 | |
| SCHEMBL6831069 | 0.75 | NAMPT (0.53) | HPGDTSHRSMN1; SMN2ALDH1A1HTT | |
| SCHEMBL7222852 | 0.75 | NPC1 (0.43) | HPGDSMN1; SMN2HSD17B10ALDH1A1RAB9A | |
| SCHEMBL6304803 | 0.74 | DRD4 (0.44) | HPGDHSD17B10ALDH1A1DRD4DRD2 | |
| SCHEMBL6834466 | 0.73 | KMT2A (0.37) | TSHRSMN1; SMN2ALDH1A1HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6653471-B2 | Tricyclic heteroaromatic compounds containing pyrrole ring; central nervous system disorder treatment; side effect reduction | NEUROGEN CORPORATION | 2003-11-25 | — | — | US | disclosed |