Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 6/20 | 0.40 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.40 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7399792 | 0.81 | AXL (0.45) | APLNRNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL7216812 | 0.81 | NPC1 (0.56) | NPC1RAB9AMAPTSMN1; SMN2HPGD | |
| SCHEMBL7217055 | 0.80 | NPC1 (0.48) | NPC1RAB9AMAPTSMN1; SMN2TP53 | |
| SCHEMBL7216469 | 0.78 | NPC1 (0.42) | NPC1RAB9AMAPTSMN1; SMN2HPGD | |
| SCHEMBL6831069 | 0.78 | NAMPT (0.53) | NPC1RAB9AMAPTSMN1; SMN2HPGD | |
| SCHEMBL7216813 | 0.77 | F10 (0.39) | NPC1RAB9ATP53MEN1KMT2A | |
| SCHEMBL7216803 | 0.77 | NR3C1 (0.41) | NPC1RAB9AMAPTSMN1; SMN2HPGD | |
| SCHEMBL7221648 | 0.77 | JAK2 (0.40) | RAB9AMEN1KMT2A | |
| SCHEMBL7223258 | 0.77 | HPGD (0.39) | NPC1RAB9AMAPTSMN1; SMN2HPGD | |
| SCHEMBL6834309 | 0.75 | LMNA (0.42) | NPC1RAB9AMAPTSMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6653471-B2 | Tricyclic heteroaromatic compounds containing pyrrole ring; central nervous system disorder treatment; side effect reduction | NEUROGEN CORPORATION | 2003-11-25 | — | — | US | disclosed |