Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP6 | P55212 | 1/20 | 0.56 |
| ▸ | FGF1 | P05230 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TIMP3 | P35625 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | PLAU | P00749 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ATIC | P31939 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7223951 | 0.93 | CASP6 (0.57) | CASP6FGF1ALDH1A1GPR27LMNA | |
| SCHEMBL7232469 | 0.88 | CASP6 (0.58) | CASP6FGF1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7230646 | 0.88 | CASP6 (0.55) | CASP6FGF1ALDH1A1LMNAGAA | |
| SCHEMBL7224703 | 0.88 | CASP6 (0.55) | CASP6FGF1ALDH1A1GPR27GAA | |
| SCHEMBL7224369 | 0.88 | CASP6 (0.57) | CASP6FGF1ALDH1A1GPR27GAA | |
| SCHEMBL7230479 | 0.88 | CASP6 (0.55) | CASP6FGF1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7223974 | 0.88 | CASP6 (0.54) | CASP6FGF1ALDH1A1LMNATIMP3 | |
| SCHEMBL6240628 | 0.86 | CASP6 (0.72) | CASP6FGF1ALDH1A1LMNATIMP3 | |
| SCHEMBL7233377 | 0.84 | CASP6 (0.60) | CASP6FGF1ALDH1A1TIMP3CYP2C9 | |
| SCHEMBL7223317 | 0.84 | CASP6 (0.55) | CASP6FGF1ALDH1A1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6653321-B1 | Stimulating kinase activity of insulin receptor; type II diabetes; hyperglycemia | TELIK, INC. | 2003-11-25 | — | — | US | disclosed |