Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP6 | P55212 | 1/20 | 0.55 |
| ▸ | WDR5 | P61964 | 1/20 | 0.52 |
| ▸ | FGF1 | P05230 | 1/20 | 0.49 |
| ▸ | TIMP3 | P35625 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 4/20 | 0.46 |
| ▸ | EGFR | P00533 | 3/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ATIC | P31939 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7223951 | 0.92 | CASP6 (0.57) | CASP6FGF1TIMP3MEN1KMT2A | |
| SCHEMBL7230646 | 0.90 | CASP6 (0.55) | CASP6FGF1TIMP3MEN1KMT2A | |
| SCHEMBL7232469 | 0.90 | CASP6 (0.58) | CASP6FGF1TIMP3MEN1KMT2A | |
| SCHEMBL7233109 | 0.89 | FGF1 (0.59) | CASP6FGF1TIMP3MEN1KMT2A | |
| SCHEMBL7223386 | 0.88 | CASP6 (0.56) | CASP6FGF1TIMP3MEN1KMT2A | |
| SCHEMBL7226724 | 0.88 | FGF1 (0.62) | CASP6FGF1TIMP3MEN1KMT2A | |
| SCHEMBL7230479 | 0.87 | CASP6 (0.55) | CASP6FGF1TIMP3MEN1KMT2A | |
| SCHEMBL6240628 | 0.85 | CASP6 (0.72) | CASP6FGF1TIMP3MEN1KMT2A | |
| SCHEMBL7233931 | 0.85 | CASP6 (0.57) | CASP6FGF1TIMP3MEN1KMT2A | |
| SCHEMBL7223974 | 0.84 | CASP6 (0.54) | CASP6FGF1TIMP3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6653321-B1 | Stimulating kinase activity of insulin receptor; type II diabetes; hyperglycemia | TELIK, INC. | 2003-11-25 | — | — | US | disclosed |