Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | ULK1 | O75385 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7230386 | 0.90 | USP30 (0.38) | PTPN11PTPN1SLC6A3KCNH2TAAR1 | |
| SCHEMBL7232579 | 0.88 | PTPN11 (0.43) | PTPN11PTPN1SLC6A3KCNH2TAAR1 | |
| SCHEMBL7232029 | 0.86 | HDAC1 (0.49) | PTPN11PTPN1USP30HDAC1HDAC6 | |
| SCHEMBL7226045 | 0.85 | USP30 (0.43) | PTPN11PTPN1SLC6A3KCNH2TAAR1 | |
| SCHEMBL7226143 | 0.85 | PTPN11 (0.49) | PTPN11PTPN1SLC6A3USP30HDAC1 | |
| SCHEMBL7224996 | 0.84 | USP30 (0.42) | PTPN11PTPN1SLC6A3KCNH2TAAR1 | |
| SCHEMBL7225979 | 0.84 | CHRNA7 (0.41) | PTPN11PTPN1KCNH2MEN1NPC1 | |
| SCHEMBL7223360 | 0.84 | MAPK11 (0.39) | USP30HDAC1HDAC6ULK1HDAC3 | |
| SCHEMBL7223371 | 0.83 | USP30 (0.42) | PTPN11PTPN1SLC6A3KCNH2TAAR1 | |
| SCHEMBL7234180 | 0.83 | USP30 (0.42) | PTPN11PTPN1SLC6A3KCNH2TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |