Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.37 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7226045 | 0.90 | USP30 (0.43) | PTPN11PTPN1USP30SLC6A3KCNH2 | |
| SCHEMBL7225370 | 0.90 | USP30 (0.42) | PTPN1USP30SMN1; SMN2FYNALDH1A1 | |
| SCHEMBL7225141 | 0.88 | USP30 (0.44) | PTPN11PTPN1USP30SLC6A3KCNH2 | |
| SCHEMBL7223409 | 0.88 | PTPN11 (0.44) | PTPN11PTPN1USP30SLC6A3KCNH2 | |
| SCHEMBL7224996 | 0.87 | USP30 (0.42) | PTPN11PTPN1USP30SLC6A3KCNH2 | |
| SCHEMBL7226373 | 0.87 | P2RX7 (0.44) | PTPN11PTPN1USP30SLC6A3KCNH2 | |
| SCHEMBL7226143 | 0.86 | PTPN11 (0.49) | PTPN11PTPN1USP30SLC6A3HDAC3 | |
| SCHEMBL7234180 | 0.86 | USP30 (0.42) | PTPN11PTPN1USP30SLC6A3KCNH2 | |
| SCHEMBL7223371 | 0.86 | USP30 (0.42) | PTPN11PTPN1USP30SLC6A3KCNH2 | |
| SCHEMBL7231198 | 0.86 | SMN1; SMN2 (0.47) | PTPN11PTPN1USP30SLC6A3HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |