Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 13/20 | 0.73 |
| ▸ | ACE | P12821 | 3/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL489801 | 1.00 | ECE1 (0.73) | ECE1ACEALOX15 | |
| SCHEMBL7230352 | 0.90 | ACE (0.61) | ECE1ACEALOX15 | |
| SCHEMBL7222010 | 0.89 | ACE (0.63) | ECE1ACE | |
| SCHEMBL7452590 | 0.87 | MME (0.56) | ECE1ACE | |
| SCHEMBL7707507 | 0.84 | ACE (0.62) | ECE1ACEALOX15 | |
| SCHEMBL8360275 | 0.83 | ALOX15 (0.61) | ECE1ACEALOX15 | |
| SCHEMBL7224961 | 0.82 | ECE1 (0.61) | ECE1ACE | |
| SCHEMBL5964512 | 0.81 | ACE (0.52) | ECE1ACE | |
| SCHEMBL5964517 | 0.81 | ACE (0.52) | ECE1ACE | |
| SCHEMBL7975953 | 0.81 | ECE1 (0.53) | ECE1ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6613782-B2 | For treating and/or preventing endothelin dependent conditions, e.g. cardio- and cerebro-vascular disorders such as hypertension, vasoconstriction, congestive heart failure, cerebral disorders, respiratory system disorders | NOVARTIS AG (CH) | 2003-09-02 | — | — | US | disclosed |
| US-6423727-B1 | Certain thiol inhibitors of endothelin-converting enzyme | NOVARTIS AG (CH) | 2002-07-23 | — | — | US | disclosed |
| US-20020082218-A1 | Certain thiol inhibitors of endothelin-converting enzyme | LOMBAERT STEPHANE DE (US) | 2002-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020082218-A1 | Certain thiol inhibitors of endothelin-converting enzyme | ECE1, ECE2, EDNRB | ECE1 1/4885ACE 10/4885ALOX15 343/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.