Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | ACE | P12821 | 3/20 | 0.60 |
| ▸ | ECE1 | P42892 | 7/20 | 0.59 |
| ▸ | ITGB2 | P05107 | 3/20 | 0.58 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.58 |
| ▸ | ITGAL | P20701 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7707507 | 0.91 | ACE (0.62) | ALOX15ACEECE1ITGB2ICAM1 | |
| SCHEMBL7222010 | 0.85 | ACE (0.63) | ACEECE1 | |
| SCHEMBL7230352 | 0.83 | ACE (0.61) | ALOX15ACEECE1ITGB2ICAM1 | |
| SCHEMBL489801 | 0.83 | ECE1 (0.73) | ALOX15ACEECE1 | |
| SCHEMBL7223833 | 0.83 | ECE1 (0.73) | ALOX15ACEECE1 | |
| SCHEMBL27798645 | 0.81 | ALOX15 (0.55) | ALOX15ACEITGB2ICAM1ITGAL | |
| SCHEMBL7452590 | 0.80 | MME (0.56) | ACEECE1 | |
| Acetyltryptophan SCHEMBL702442 | 0.79 | ALOX15 (0.79) | ALOX15ACEECE1ITGB2ICAM1 | |
| Acetyltryptophan SCHEMBL57141 | 0.79 | ALOX15 (0.79) | ALOX15ACEECE1ITGB2ICAM1 | |
| Acetyltryptophan SCHEMBL57140 | 0.79 | ALOX15 (0.79) | ALOX15ACEECE1ITGB2ICAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6509330-B2 | Angiotensin converting enzyme (ACE); neutral endopeptidase (NEP); containing a dipeptide derived from an amino acid, or a conformationally restricted dipeptide mimic | BRISTOL-MYERS SQUIBB COMPANY | 2003-01-21 | — | — | US | disclosed |