Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.35 |
| ▸ | HTR3B | O95264 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.35 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7225473 | 0.90 | MAPK11 (0.42) | MAPK11MAPK14USP30HTR3EHTR3B | |
| SCHEMBL7223360 | 0.88 | MAPK11 (0.39) | MAPK11MAPK14USP30HTR3EHTR3B | |
| SCHEMBL7231132 | 0.87 | MAPK11 (0.42) | MAPK11MAPK14USP30HTR3EHTR3B | |
| SCHEMBL7225952 | 0.86 | MAPK14 (0.45) | MAPK11MAPK14USP30HTR3EHTR3B | |
| SCHEMBL7226023 | 0.86 | USP30 (0.41) | MAPK11MAPK14USP30HTR3EHTR3B | |
| SCHEMBL7234311 | 0.85 | USP30 (0.39) | MAPK11MAPK14USP30HTR3EHTR3B | |
| SCHEMBL7075331 | 0.85 | USP30 (0.39) | MAPK11MAPK14USP30HTR3EHTR3B | |
| SCHEMBL7233186 | 0.84 | USP30 (0.39) | MAPK11MAPK14USP30HTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL7077995 | 0.84 | USP30 (0.39) | MAPK11MAPK14USP30HTR3EHTR3B | |
| SCHEMBL7230337 | 0.84 | MAPK11 (0.49) | MAPK11MAPK14USP30HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |