Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.37 |
| ▸ | HTR3B | O95264 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.37 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 3/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | HCK | P08631 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7226023 | 0.90 | USP30 (0.41) | MAPK14MAPK11USP30HTR3EHTR3B | |
| SCHEMBL7234311 | 0.89 | USP30 (0.39) | MAPK14MAPK11USP30HTR3EHTR3B | |
| SCHEMBL7075331 | 0.89 | USP30 (0.39) | MAPK14MAPK11USP30HTR3EHTR3B | |
| SCHEMBL7225473 | 0.88 | MAPK11 (0.42) | MAPK14MAPK11USP30HTR3EHTR3B | |
| SCHEMBL7230337 | 0.88 | MAPK11 (0.49) | MAPK14MAPK11USP30HTR3EHTR3B | |
| SCHEMBL7233186 | 0.88 | USP30 (0.39) | MAPK14MAPK11USP30HTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL7077995 | 0.88 | USP30 (0.39) | MAPK14MAPK11USP30HTR3EHTR3B | |
| SCHEMBL7233270 | 0.87 | HDAC3 (0.48) | MAPK14MAPK11USP30HTR3EHTR3B | |
| SCHEMBL7224115 | 0.86 | MAPK11 (0.43) | MAPK14MAPK11USP30HTR3EHTR3B | |
| SCHEMBL7231086 | 0.85 | USP30 (0.43) | MAPK14MAPK11USP30HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |