Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | SOAT1 | P35610 | 3/20 | 0.45 |
| ▸ | SOAT2 | O75908 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3408925 | 0.86 | SMN1; SMN2 (0.70) | SMN1; SMN2KMT2AMEN1TDP1SOAT1 | |
| SCHEMBL7224403 | 0.86 | NLRP3 (0.43) | SMN1; SMN2KMT2AMEN1TDP1LMNA | |
| SCHEMBL7225295 | 0.86 | SMN1; SMN2 (0.75) | SMN1; SMN2KMT2AMEN1TDP1SOAT1 | |
| Benzene SCHEMBL9851028 | 0.85 | SMN1; SMN2 (0.68) | SMN1; SMN2KMT2AMEN1TDP1SOAT1 | |
| SCHEMBL7223579 | 0.81 | NLRP3 (0.56) | KMT2AMEN1LMNAMAPTNLRP3 | |
| SCHEMBL15804674 | 0.81 | KMT2A (0.59) | SMN1; SMN2KMT2AMEN1TDP1SOAT1 | |
| SCHEMBL7223730 | 0.79 | ALOX15 (0.52) | SMN1; SMN2TDP1LMNAKDM4EMAPT | |
| SCHEMBL7218234 | 0.79 | L3MBTL1 (0.46) | KMT2AMEN1TDP1LMNAKDM4E | |
| SCHEMBL7223137 | 0.77 | NAMPT (0.41) | KMT2AMEN1LMNAKDM4ENLRP3 | |
| SCHEMBL7219696 | 0.76 | SMN1; SMN2 (0.56) | SMN1; SMN2KMT2AMEN1TDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6521603-B2 | Amide, thioamide, amidine and thioester derivatives containing a benzene, pyridine, thiophene, furan, pyrrole, pyrazole, thiazole or isothiazole ring | MONSANTO TECHNOLOGY LLC | 2003-02-18 | — | — | US | claimed |