Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 5/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.39 |
| ▸ | HTR3B | O95264 | 4/20 | 0.39 |
| ▸ | HTR3A | P46098 | 4/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.39 |
| ▸ | F10 | P00742 | 11/20 | 0.39 |
| ▸ | F2 | P00734 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESRRG | P62508 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7224677 | 0.93 | MEN1 (0.43) | F10F2MEN1GAAHTT | |
| Hydrochloric Acid SCHEMBL7233032 | 0.91 | F10 (0.43) | F10F2MEN1GAAHTT | |
| SCHEMBL7231972 | 0.86 | ESRRG (0.46) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7224299 | 0.86 | NPC1 (0.45) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7231089 | 0.85 | CHRNA7 (0.37) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7224323 | 0.85 | MEN1 (0.38) | F10F2MEN1GAAHTT | |
| SCHEMBL7234416 | 0.85 | F10 (0.37) | F10F2MEN1GAAHTT | |
| SCHEMBL7223422 | 0.85 | HPGD (0.38) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7223518 | 0.84 | CHRNA7 (0.60) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7223682 | 0.84 | AKT1 (0.40) | CHRNA7HTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |