Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.53 |
| ▸ | PPARA | Q07869 | 3/20 | 0.49 |
| ▸ | PPARG | P37231 | 2/20 | 0.49 |
| ▸ | CYP4F2 | P78329 | 4/20 | 0.48 |
| ▸ | CYP4A11 | Q02928 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CYP4Z1 | Q86W10 | 2/20 | 0.46 |
| ▸ | CYP4F11 | Q9HBI6 | 1/20 | 0.46 |
| ▸ | CYP4F12 | Q9HCS2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7784074 | 0.97 | ALOX5 (0.53) | ALOX5PPARAPPARGCYP4F2CYP4A11 | |
| SCHEMBL765924 | 0.84 | ALOX5 (0.57) | ALOX5PPARAPPARGCYP4F2CYP4A11 | |
| SCHEMBL19089791 | 0.84 | ALOX5 (0.57) | ALOX5PPARAPPARGCYP4F2CYP4A11 | |
| SCHEMBL3906464 | 0.82 | ALOX5 (0.56) | ALOX5PPARAPPARGCYP4F2CYP4A11 | |
| SCHEMBL6294282 | 0.81 | ALOX5 (0.54) | ALOX5PPARAPPARGCYP4F2CYP4A11 | |
| SCHEMBL19899012 | 0.81 | ALOX5 (0.54) | ALOX5PPARAPPARGCYP4F2CYP4A11 | |
| SCHEMBL1068777 | 0.81 | ALOX5 (0.54) | ALOX5PPARAPPARGCYP4F2CYP4A11 | |
| SCHEMBL11588395 | 0.81 | ALOX5 (0.54) | ALOX5PPARAPPARGCYP4F2CYP4A11 | |
| SCHEMBL19078963 | 0.81 | ALOX5 (0.54) | ALOX5PPARAPPARGCYP4F2CYP4A11 | |
| SCHEMBL642197 | 0.81 | ALOX5 (0.54) | ALOX5PPARAPPARGCYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6593480-B2 | Obesity, hyperglycemia | ABBOTT LABORATORIES | 2003-07-15 | — | — | US | disclosed |
| WO-2002070507-A2 | GLYCORTICOID RECEPTOR ANTAGONISTS FOR TREATMENT OF DIABETES | ABBOTT LABORATORIES (US) | 2002-09-12 | — | — | WO | disclosed |
| US-20010041802-A1 | Glucocorticoid receptor antagonists for treatment of diabetes | KARO BIO AB (SE) | 2001-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010041802-A1 | Glucocorticoid receptor antagonists for treatment of diabetes | NR3C1, GPR119, NR3C2 | ALOX5 532/4885PPARA 203/4885PPARG 49/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.