Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK11 | Q15759 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ESRRG | P62508 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 6/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 5/20 | 0.42 |
| ▸ | HTR3B | O95264 | 5/20 | 0.42 |
| ▸ | HTR3A | P46098 | 5/20 | 0.42 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 0.42 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7224412 | 0.91 | CHRNA7 (0.44) | MAPK11MAPK14PTPN11PTPN1ESR1 | |
| SCHEMBL7225979 | 0.86 | CHRNA7 (0.41) | MAPK11MAPK14PTPN11PTPN1ESR1 | |
| SCHEMBL7231972 | 0.86 | ESRRG (0.46) | MAPK11MAPK14PTPN11PTPN1ESR1 | |
| SCHEMBL7224991 | 0.86 | ESRRG (0.46) | MAPK11MAPK14PTPN11PTPN1ESR1 | |
| SCHEMBL7224193 | 0.86 | HDAC3 (0.53) | MAPK11MAPK14PTPN11PTPN1ESR1 | |
| SCHEMBL375517 | 0.85 | CHRNA7 (0.57) | MAPK11MAPK14PTPN11PTPN1ESR1 | |
| SCHEMBL7223338 | 0.85 | CHRNA7 (0.57) | MAPK11MAPK14PTPN11PTPN1ESR1 | |
| SCHEMBL7224594 | 0.84 | CHRNA7 (0.40) | MAPK11MAPK14PTPN11PTPN1ESR1 | |
| SCHEMBL7224563 | 0.84 | PTPN1 (0.49) | MAPK11MAPK14PTPN11PTPN1ESR1 | |
| SCHEMBL7232519 | 0.84 | MAPK11 (0.48) | MAPK11MAPK14PTPN11PTPN1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |