Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | BCAT2 | O15382 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7071274 | 0.86 | USP30 (0.53) | ALDH1A1NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL7232138 | 0.86 | USP30 (0.36) | ALDH1A1CHRNA7USP30 | |
| SCHEMBL7224345 | 0.85 | CHRNA7 (0.60) | CHRNA7NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL374986 | 0.85 | CHRNA7 (0.60) | CHRNA7NPC1MAPTRAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7075524 | 0.85 | USP30 (0.52) | ALDH1A1NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL7234885 | 0.85 | GSK3B (0.35) | CHRNA7USP30 | |
| SCHEMBL7226932 | 0.84 | SLC6A3 (0.37) | CHRNA7USP30HDAC3HDAC4HDAC1 | |
| Hydrochloric Acid SCHEMBL7231896 | 0.84 | CHRNA7 (0.59) | CHRNA7NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL7075331 | 0.83 | USP30 (0.39) | ALDH1A1NPC1RAB9ASMN1; SMN2USP30 | |
| SCHEMBL7234311 | 0.83 | USP30 (0.39) | NPC1RAB9AUSP30HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |