Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7224766 | 0.86 | ALDH1A1 (0.49) | USP30ALDH1A1CHRNA7 | |
| SCHEMBL7223521 | 0.86 | PIM1 (0.39) | USP30CHRNB2CHRNA4SLC6A3CHRNA7 | |
| SCHEMBL7233042 | 0.85 | USP30 (0.36) | USP30CHRNB2CHRNA4SLC6A3CHRNA7 | |
| SCHEMBL7226932 | 0.85 | SLC6A3 (0.37) | USP30SLC6A3CHRNA7PTPN11 | |
| SCHEMBL7075331 | 0.84 | USP30 (0.39) | USP30CHRNB2CHRNA4ALDH1A1IRAK4 | |
| SCHEMBL7234885 | 0.83 | GSK3B (0.35) | USP30CHRNB2CHRNA4SLC6A3CHRNA7 | |
| SCHEMBL7223211 | 0.83 | USP30 (0.41) | USP30CHRNB2CHRNA4PTPN11 | |
| Hydrochloric Acid SCHEMBL7077995 | 0.83 | USP30 (0.39) | USP30CHRNB2CHRNA4ALDH1A1IRAK4 | |
| SCHEMBL7233938 | 0.83 | USP30 (0.37) | USP30CHRNB2CHRNA4IRAK4LIPG | |
| SCHEMBL7226143 | 0.82 | PTPN11 (0.49) | USP30CHRNB2CHRNA4SLC6A3PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |