Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | ULK1 | O75385 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7226143 | 0.88 | PTPN11 (0.49) | SLC6A3PTPN11USP30ULK1HDAC9 | |
| SCHEMBL7234885 | 0.86 | GSK3B (0.35) | SLC6A3PTPN11USP30ULK1CHRNA7 | |
| SCHEMBL7232138 | 0.85 | USP30 (0.36) | SLC6A3PTPN11USP30CHRNA7 | |
| SCHEMBL7224766 | 0.84 | ALDH1A1 (0.49) | USP30CHRNA7HDAC9HDAC3HDAC4 | |
| SCHEMBL7227071 | 0.84 | HDAC3 (0.44) | SLC6A3PTPN11ULK1CHRNA7HDAC9 | |
| SCHEMBL7225497 | 0.84 | HDAC3 (0.37) | SLC6A3PTPN11ULK1CHRNA7HDAC9 | |
| SCHEMBL7231825 | 0.83 | USP30 (0.38) | SLC6A3PTPN11USP30ULK1CHRNA7 | |
| SCHEMBL7223521 | 0.82 | PIM1 (0.39) | SLC6A3USP30CHRNA7 | |
| SCHEMBL7075331 | 0.82 | USP30 (0.39) | USP30 | |
| SCHEMBL7224688 | 0.82 | SLC6A3 (0.36) | SLC6A3USP30BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |