Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | CTSC | P53634 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7232113 | 0.89 | USP30 (0.47) | USP30CYP3A4CYP2D6CYP2C19SLC6A3 | |
| SCHEMBL7230934 | 0.87 | KDM1A (0.43) | USP30CYP3A4SLC6A3CHRNB2CHRNA4 | |
| SCHEMBL7224277 | 0.86 | USP30 (0.43) | USP30AXLMERTKCHRNB2CHRNA4 | |
| SCHEMBL7223211 | 0.86 | USP30 (0.41) | USP30PAX8CHRNB2CHRNA4NPC1 | |
| SCHEMBL7225292 | 0.86 | P2RX7 (0.43) | USP30SLC6A3AXLMERTKCHRNB2 | |
| SCHEMBL7224212 | 0.86 | USP30 (0.41) | USP30SLC6A3CHRNB2CHRNA4NPC1 | |
| SCHEMBL7226302 | 0.86 | NPC1 (0.52) | USP30CYP2D6CYP2C19CHRNB2CHRNA4 | |
| SCHEMBL7071274 | 0.85 | USP30 (0.53) | USP30CYP3A4CYP2D6CYP2C19SLC6A3 | |
| Hydrochloric Acid SCHEMBL7075524 | 0.84 | USP30 (0.52) | USP30CYP3A4CYP2D6CYP2C19SLC6A3 | |
| SCHEMBL7232527 | 0.84 | USP30 (0.42) | USP30SLC6A3HTR3ACHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |