Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CTSC | P53634 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | NAAA | Q02083 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7224838 | 0.89 | USP30 (0.46) | USP30CHRNB2CHRNA4CYP3A4CYP2D6 | |
| SCHEMBL7224996 | 0.89 | USP30 (0.42) | USP30CHRNB2CHRNA4PTPN1PTPN11 | |
| SCHEMBL7226143 | 0.88 | PTPN11 (0.49) | USP30CHRNB2CHRNA4PTPN1PTPN11 | |
| SCHEMBL7225141 | 0.88 | USP30 (0.44) | USP30PTPN1PTPN11CNR1SLC6A3 | |
| SCHEMBL7234180 | 0.88 | USP30 (0.42) | USP30PTPN1PTPN11CNR1SLC6A3 | |
| SCHEMBL7223371 | 0.88 | USP30 (0.42) | USP30CHRNB2CHRNA4PTPN1PTPN11 | |
| SCHEMBL7231198 | 0.88 | SMN1; SMN2 (0.47) | USP30CYP2D6CYP2C19PTPN1PTPN11 | |
| SCHEMBL7071274 | 0.87 | USP30 (0.53) | USP30CHRNB2CHRNA4CYP3A4CYP2D6 | |
| SCHEMBL7223173 | 0.86 | CDC7 (0.43) | USP30CYP3A4PTPN1PAX8PTPN11 | |
| Hydrochloric Acid SCHEMBL7075524 | 0.86 | USP30 (0.52) | USP30CHRNB2CHRNA4CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |