Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 13/20 | 0.45 |
| ▸ | GAA | P10253 | 13/20 | 0.45 |
| ▸ | SI | P14410 | 13/20 | 0.45 |
| ▸ | MGAM2 | Q2M2H8 | 13/20 | 0.45 |
| ▸ | NPC1 | O15118 | 7/20 | 0.42 |
| ▸ | RAB9A | P51151 | 7/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7224538 | 0.92 | MGAM (0.44) | MGAMGAASIMGAM2NPC1 | |
| SCHEMBL7233542 | 0.85 | MGAM (0.43) | MGAMGAASIMGAM2NPC1 | |
| SCHEMBL7224769 | 0.83 | RAB9A (0.39) | MGAMGAASIMGAM2NPC1 | |
| SCHEMBL7223398 | 0.83 | NPC1 (0.39) | MGAMGAASIMGAM2NPC1 | |
| SCHEMBL7232692 | 0.82 | NPC1 (0.42) | GAANPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL7224791 | 0.82 | NPC1 (0.44) | GAANPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL7223990 | 0.81 | RAB9A (0.42) | GAANPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL7223992 | 0.81 | RAB9A (0.42) | GAANPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL7225482 | 0.81 | ALDH1A1 (0.54) | MGAMGAASIMGAM2NPC1 | |
| SCHEMBL7232719 | 0.81 | NPC1 (0.43) | GAANPC1RAB9AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |