Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 5/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 3/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7234785 | 0.94 | PIM1 (0.34) | PIM1PIM3PIM2USP30CHRNB2 | |
| SCHEMBL7075331 | 0.89 | USP30 (0.39) | PIM1PIM3USP30CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL7077995 | 0.88 | USP30 (0.39) | PIM1PIM3USP30CHRNB2CHRNA4 | |
| SCHEMBL7227071 | 0.86 | HDAC3 (0.44) | CHRNB2CHRNA4SLC6A3 | |
| SCHEMBL7225497 | 0.86 | HDAC3 (0.37) | PIM1CHRNB2CHRNA4SLC6A3 | |
| SCHEMBL7223173 | 0.85 | CDC7 (0.43) | CYP3A4USP30SLC6A3 | |
| SCHEMBL7223374 | 0.84 | CHRNB2 (0.36) | USP30CHRNB2CHRNA4 | |
| SCHEMBL7233042 | 0.84 | USP30 (0.36) | PIM1PIM3PIM2USP30CHRNB2 | |
| SCHEMBL7223521 | 0.83 | PIM1 (0.39) | PIM1PIM3PIM2USP30CHRNB2 | |
| SCHEMBL7225628 | 0.82 | USP30 (0.36) | PIM1PIM3PIM2USP30CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |