Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7075331 | 0.89 | USP30 (0.39) | CHRNB2CHRNA4USP30MAPK11MAPK14 | |
| Hydrochloric Acid SCHEMBL7077995 | 0.88 | USP30 (0.39) | CHRNB2CHRNA4USP30MAPK11MAPK14 | |
| SCHEMBL7225628 | 0.86 | USP30 (0.36) | CHRNB2CHRNA4USP30 | |
| SCHEMBL7233042 | 0.86 | USP30 (0.36) | CHRNB2CHRNA4USP30MAPK11MAPK14 | |
| SCHEMBL7234311 | 0.85 | USP30 (0.39) | USP30MAPK11MAPK14 | |
| SCHEMBL7225191 | 0.84 | ADORA2B (0.35) | CHRNB2CHRNA4USP30 | |
| SCHEMBL7234785 | 0.84 | PIM1 (0.34) | CHRNB2CHRNA4USP30MAPK11MAPK14 | |
| SCHEMBL7225952 | 0.84 | MAPK14 (0.45) | USP30MAPK11MAPK14 | |
| SCHEMBL7233186 | 0.84 | USP30 (0.39) | USP30MAPK11MAPK14 | |
| SCHEMBL7230337 | 0.84 | MAPK11 (0.49) | USP30MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |