Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | CCR2 | P41597 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5870761 | 0.83 | OPRM1 (0.50) | KMT2AOPRM1SIGMAR1LTA4HEPHX2 | |
| SCHEMBL5871105 | 0.78 | SMN1; SMN2 (0.53) | KMT2AOPRM1LTA4HEPHX2CHRNB2 | |
| SCHEMBL5870735 | 0.76 | CHRNB2 (0.46) | KDM4EKMT2AOPRM1LTA4HEPHX2 | |
| SCHEMBL7226706 | 0.76 | OPRM1 (0.51) | KMT2AOPRM1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL5870682 | 0.75 | OPRD1 (0.62) | OPRM1SIGMAR1CHRNA4 | |
| SCHEMBL5870753 | 0.75 | OPRD1 (0.62) | OPRM1SIGMAR1CHRNA4 | |
| SCHEMBL5870685 | 0.75 | OPRD1 (0.62) | OPRM1SIGMAR1CHRNA4 | |
| SCHEMBL5870834 | 0.74 | OPRM1 (0.55) | OPRM1SIGMAR1CHRNA4 | |
| SCHEMBL5870832 | 0.74 | OPRM1 (0.55) | OPRM1SIGMAR1CHRNA4 | |
| SCHEMBL5870894 | 0.73 | OPRD1 (0.49) | KMT2AOPRM1CHRNB2CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6645980-B1 | Ligands for biological receptors such as opiate receptors or G-protein coupled receptors used for treating pain, drug dependence or tinnitus in mammals | SEPRACOR INC. | 2003-11-11 | — | — | US | disclosed |