Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | ECE1 | P42892 | 1/20 | 0.48 |
| ▸ | CPB1 | P15086 | 1/20 | 0.48 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.47 |
| ▸ | TLR2 | O60603 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ANPEP | P15144 | 1/20 | 0.45 |
| ▸ | EPOR | P19235 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7226853 | 1.00 | MMP2 (0.50) | MMP2MMP9ECE1CPB1CPB2 | |
| Methane SCHEMBL28261132 | 0.99 | MMP2 (0.49) | MMP2MMP9ECE1CPB1CPB2 | |
| SCHEMBL3982664 | 0.96 | NPC1 (0.46) | MMP2MMP9ECE1CPB1CPB2 | |
| Charcoal, Activated SCHEMBL29433728 | 0.87 | ANPEP (0.55) | ECE1CPB1CPB2LTA4HTLR2 | |
| Hydrochloric Acid SCHEMBL29433727 | 0.85 | ANPEP (0.54) | ECE1CPB1CPB2LTA4HTLR2 | |
| SCHEMBL28937048 | 0.84 | LTA4H (0.46) | MMP2LTA4HNPC1RAB9A | |
| SCHEMBL9556097 | 0.84 | LTA4H (0.46) | MMP2LTA4HNPC1RAB9A | |
| SCHEMBL6158695 | 0.84 | CA1 (0.59) | MMP2ECE1 | |
| SCHEMBL6158692 | 0.84 | CA1 (0.59) | MMP2ECE1 | |
| SCHEMBL9440248 | 0.83 | FOLH1 (0.53) | MMP2MMP9CPB1CPB2ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6576780-B1 | Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors | GD SEARLE & COMPANY | 2003-06-10 | — | — | US | disclosed |
| US-6207708-B1 | FOR THERAPY AND PROPHYLAXIS OF AUTOIMMUNE AND/OR INFLAMMATORY CONDITIONS AFFECTING THE JOINTS SUCH AS ARTHRITIS, AND INFLAMMATORY BOWEL DISEASE, CARDIVASCULAR ISCHEMIA, DIABETES, CONGESTIVE HEART FAILURE, MYOCARDITIS, ATHEROSCLEROSIS, | G. D. SEARLE & COMPANY | 2001-03-27 | — | — | US | disclosed |
| EP-0885188-B1 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2000-09-27 | — | — | EP | disclosed |
| US-5981511-A | AN ENZYME INHIBITOR FOR REDUCING NITRIC OXIDE, TREATING HYPOTENSION SUCH AS TOXIC SHOCK AND THERAPY WITH CERTAIN CYTOKINES | G.D. SEARLE & CO. (US) | 1999-11-09 | — | — | US | disclosed |
| EP-0885188-A1 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997032844-A9 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | — | 1997-12-24 | — | — | WO | disclosed |
| WO-1997032844-A1 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1997-09-12 | — | — | WO | disclosed |
| EP-0154343-B1 | ADSORBENT | Research Development Corporation of Japan (JP) | 1991-06-19 | — | — | EP | disclosed |
| US-4785021-A | OPTICAL RESOLUTION | RESEARCH DEVELOPMENT CORP. OF JAPAN (JP) | 1988-11-15 | — | — | US | disclosed |
| US-4694044-A | Adsorbent | RESEARCH DEVELOPMENT CORP. OF JAPAN (JP) | 1987-09-15 | — | — | US | disclosed |
| EP-0154343-A2 | Adsorbent | Research Development Corporation of Japan (JP) | 1985-09-11 | — | — | EP | disclosed |