Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | AKT2 | P31751 | 7/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.39 |
| ▸ | LSS | P48449 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | CLK3 | P49761 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7227276 | 1.00 | JAK3 (0.42) | JAK3AKT2PDK2PDK4LSS | |
| SCHEMBL7233874 | 0.91 | RAB9A (0.38) | JAK3AKT2LSSROCK2PDPK1 | |
| SCHEMBL7233883 | 0.91 | RAB9A (0.38) | JAK3AKT2LSSROCK2PDPK1 | |
| SCHEMBL7235053 | 0.90 | ACHE (0.45) | JAK3 | |
| SCHEMBL7235050 | 0.90 | ACHE (0.45) | JAK3 | |
| SCHEMBL7234212 | 0.89 | ALDH1A1 (0.39) | JAK3AKT2LSSROCK2PDPK1 | |
| SCHEMBL8188477 | 0.89 | HTT (0.46) | JAK3AKT2ROCK2PDPK1AKT1 | |
| SCHEMBL7234207 | 0.89 | ALDH1A1 (0.39) | JAK3AKT2LSSROCK2PDPK1 | |
| SCHEMBL8188481 | 0.89 | HTT (0.46) | JAK3AKT2ROCK2PDPK1AKT1 | |
| SCHEMBL7225609 | 0.89 | JAK3 (0.42) | JAK3AKT2ROCK2PDPK1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6545035-B1 | Having effect on various kinases and cycline/CDK complexes and on the proliferation of various tumour cells. | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-04-08 | — | — | US | disclosed |