SCHEMBL7225614

SCHEMBL7225614

COC(=O)C(C)Oc1cccc(COc2cc(-n3c(=O)cc(C(F)(F)F)n(C)c3=O)c(F)cc2Cl)c1

nearest known ligand 0.38

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
MRGPRX4 Q96LA9 10/20 0.38
PPOX P50336 3/20 0.38
DHODH Q02127 6/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7227471 0.92 POLB (0.36) MRGPRX4PPOXDHODH
SCHEMBL7227640 0.92 MRGPRX4 (0.39) MRGPRX4PPOXDHODH
SCHEMBL7234497 0.88 DHODH (0.38) PPOXDHODH
SCHEMBL7219416 0.87 DHODH (0.37) MRGPRX4PPOXDHODH
SCHEMBL7221822 0.86 DHODH (0.37) PPOXDHODH
SCHEMBL7219980 0.86 FFAR1 (0.40) MRGPRX4PPOX
SCHEMBL12981626 0.85 PPOX (0.43) PPOXDHODH
SCHEMBL7178022 0.85 PPOX (0.43) PPOXDHODH
SCHEMBL7227149 0.85 MEN1 (0.39) PPOXDHODH
SCHEMBL7225862 0.84 PPARG (0.37) MRGPRX4PPOXDHODH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6664214-B1 Uracil compounds and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2003-12-16 US disclosed