Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 10/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7237655 | 0.91 | GRM2 (0.55) | GRM2MMP2MMP9TDP1ADAM17 | |
| SCHEMBL7229200 | 0.89 | ITGB3 (0.50) | GRM2TDP1 | |
| SCHEMBL7227808 | 0.85 | GRM2 (0.49) | GRM2 | |
| SCHEMBL7228277 | 0.84 | GRM2 (0.47) | GRM2 | |
| SCHEMBL7236196 | 0.83 | ITGB3 (0.57) | GRM2MMP9TDP1 | |
| SCHEMBL7984346 | 0.81 | TDP1 (0.56) | MMP2MMP9TDP1ADAMTS4MMP13 | |
| SCHEMBL7229264 | 0.81 | GRM2 (0.47) | GRM2 | |
| SCHEMBL7236706 | 0.78 | GRM2 (0.46) | GRM2MMP2MMP9ADAMTS4MMP13 | |
| SCHEMBL7230540 | 0.77 | ITGB3 (0.52) | GRM2TDP1 | |
| SCHEMBL8139593 | 0.77 | GRM2 (0.57) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602876-B1 | Adhesion receptor antagonists | MERCK PATENT GMBH (DE) | 2003-08-05 | — | — | US | disclosed |
| US-6204280-B1 | OXAZOLIDINONE DERIVATIVE, ANTICOAGULANT | MERCK PATENT GESELLSCHAFT MIT BERSCHRANKTER HAFTUNG (DE) | 2001-03-20 | — | — | US | disclosed |
| EP-0710657-B1 | Antagonists of adhesion receptors | MERCK PATENT GMBH (DE) | 1998-08-26 | — | — | EP | disclosed |
| EP-0710657-A1 | Antagonists of adhesion receptors | MERCK PATENT GmbH (DE) | 1996-05-08 | — | — | EP | disclosed |