Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.38 |
| ▸ | VCAM1 | P19320 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.38 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.38 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.38 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6501572 | 0.85 | TSHR (0.48) | TSHRMAPK1GPR35CYP3A4VCAM1 | |
| SCHEMBL909526 | 0.85 | TSHR (0.44) | TSHRMAPK1GPR35CYP3A4VCAM1 | |
| SCHEMBL6152635 | 0.82 | TSHR (0.43) | TSHRMAPK1GPR35CYP3A4ALDH1A1 | |
| SCHEMBL11449422 | 0.82 | MAPT (0.41) | TSHRMAPK1GPR35CYP3A4ALDH1A1 | |
| SCHEMBL9386232 | 0.82 | TDP1 (0.46) | TSHRMAPK1GPR35CYP3A4VCAM1 | |
| SCHEMBL7749473 | 0.82 | ALDH1A1 (0.44) | TSHRMAPK1GPR35CYP3A4VCAM1 | |
| SCHEMBL8664809 | 0.77 | ALDH1A1 (0.51) | TSHRMAPK1GPR35CYP3A4VCAM1 | |
| SCHEMBL2886629 | 0.76 | CYP3A4 (0.39) | TSHRMAPK1GPR35CYP3A4ALDH1A1 | |
| SCHEMBL11131985 | 0.75 | MAPK1 (0.43) | TSHRMAPK1VCAM1ALDH1A1HPGD | |
| SCHEMBL7745381 | 0.74 | MAPT (0.42) | MAPK1ALDH1A1LMNAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6534518-B1 | Phosphodiesterase inhibitors for respiratory system disorders | ALTANA PHARMA AG (DE) | 2003-03-18 | — | — | US | disclosed |
| EP-1163226-A1 | POLYSUBSTITUTED 6-PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000042018-A1 | POLYSUBSTITUTED 6-PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2000-07-20 | — | — | WO | disclosed |