Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 5/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7231433 | 0.93 | ITGB3 (0.47) | YAP1SCN9AHRH2HRH1ITGB3 | |
| SCHEMBL7237796 | 0.84 | MAPK1 (0.41) | YAP1 | |
| SCHEMBL7228364 | 0.83 | YAP1 (0.48) | YAP1HRH2HRH1CACNA1B | |
| SCHEMBL7229032 | 0.82 | HRH2 (0.47) | YAP1HRH2HRH1ITGB3ITGA2B | |
| SCHEMBL7237702 | 0.82 | HRH2 (0.47) | YAP1HRH2HRH1ITGB3ITGA2B | |
| SCHEMBL7235737 | 0.81 | ITGB3 (0.45) | YAP1ITGB3ITGA2B | |
| SCHEMBL7228437 | 0.80 | YAP1 (0.42) | YAP1SCN9AHRH2HRH1ITGB3 | |
| SCHEMBL7229147 | 0.80 | MAPK1 (0.38) | — | |
| SCHEMBL7230827 | 0.79 | MAPK1 (0.39) | YAP1HRH2HRH1ITGB3ITGA2B | |
| SCHEMBL7231437 | 0.79 | MAPK1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602876-B1 | Adhesion receptor antagonists | MERCK PATENT GMBH (DE) | 2003-08-05 | — | — | US | disclosed |
| US-6204280-B1 | OXAZOLIDINONE DERIVATIVE, ANTICOAGULANT | MERCK PATENT GESELLSCHAFT MIT BERSCHRANKTER HAFTUNG (DE) | 2001-03-20 | — | — | US | disclosed |
| EP-0710657-B1 | Antagonists of adhesion receptors | MERCK PATENT GMBH (DE) | 1998-08-26 | — | — | EP | disclosed |
| EP-0710657-A1 | Antagonists of adhesion receptors | MERCK PATENT GmbH (DE) | 1996-05-08 | — | — | EP | disclosed |