Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 4/20 | 0.37 |
| ▸ | YAP1 | P46937 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 3/20 | 0.35 |
| ▸ | HRH1 | P35367 | 3/20 | 0.35 |
| ▸ | REN | P00797 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.35 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7235378 | 0.94 | ITGB3 (0.45) | MAPK1L3MBTL1ITGB3ITGA2BSRC | |
| SCHEMBL7239126 | 0.88 | MAPK1 (0.41) | MAPK1L3MBTL1ITGB3ITGA2BYAP1 | |
| SCHEMBL7235241 | 0.83 | ITGB3 (0.44) | MAPK1L3MBTL1ITGB3ITGA2B | |
| SCHEMBL7229032 | 0.82 | HRH2 (0.47) | MAPK1L3MBTL1ITGB3ITGA2BYAP1 | |
| SCHEMBL7237702 | 0.81 | HRH2 (0.47) | MAPK1L3MBTL1ITGB3ITGA2BYAP1 | |
| SCHEMBL7228364 | 0.79 | YAP1 (0.48) | YAP1HRH2HRH1CACNA1B | |
| SCHEMBL7229145 | 0.79 | YAP1 (0.46) | ITGB3ITGA2BSRCYAP1HRH2 | |
| SCHEMBL7228788 | 0.76 | HRH2 (0.49) | MAPK1L3MBTL1ITGB3ITGA2BYAP1 | |
| SCHEMBL7231440 | 0.74 | HRH2 (0.49) | MAPK1L3MBTL1ITGB3ITGA2BYAP1 | |
| SCHEMBL7229264 | 0.74 | GRM2 (0.47) | ITGB3ITGA2BYAP1PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602876-B1 | Adhesion receptor antagonists | MERCK PATENT GMBH (DE) | 2003-08-05 | — | — | US | disclosed |
| US-6204280-B1 | OXAZOLIDINONE DERIVATIVE, ANTICOAGULANT | MERCK PATENT GESELLSCHAFT MIT BERSCHRANKTER HAFTUNG (DE) | 2001-03-20 | — | — | US | disclosed |
| EP-0710657-B1 | Antagonists of adhesion receptors | MERCK PATENT GMBH (DE) | 1998-08-26 | — | — | EP | disclosed |
| EP-0710657-A1 | Antagonists of adhesion receptors | MERCK PATENT GmbH (DE) | 1996-05-08 | — | — | EP | disclosed |