Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 2/20 | 0.43 |
| ▸ | NPBWR1 | P48145 | 9/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.42 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8425554 | 0.76 | CA1 (0.44) | KMT2AMEN1ALDH1A1CA12CA1 | |
| SCHEMBL6535223 | 0.71 | PCNA (0.49) | CYP1A2CYP2C9SMN1; SMN2HPGD | |
| SCHEMBL7937662 | 0.71 | PCNA (0.47) | LTA4HCYP1A2CYP2C9SMN1; SMN2HPGD | |
| Formic Acid Methyl Ester SCHEMBL28279052 | 0.71 | ALDH1A1 (0.44) | KMT2AMEN1ALDH1A1CA12CA1 | |
| SCHEMBL5146420 | 0.71 | ALDH1A1 (0.55) | KMT2AMEN1ALDH1A1CA12CA1 | |
| SCHEMBL166536 | 0.69 | CA1 (0.79) | KMT2AMEN1ALDH1A1CA12CA1 | |
| SCHEMBL83811 | 0.69 | CA1 (0.79) | KMT2AMEN1ALDH1A1CA12CA1 | |
| SCHEMBL11580995 | 0.69 | CA1 (0.79) | KMT2AMEN1ALDH1A1CA12CA1 | |
| SCHEMBL4431892 | 0.69 | MAPT (0.48) | ALDH1A1CA1CA2RAB9ACYP3A4 | |
| SCHEMBL6135835 | 0.69 | TPMT (0.58) | KMT2AMEN1CA1CA2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6630489-B1 | Quinoline derivatives as tyrosine kinase inhibitors | ASTRAZENECA AB (SE) | 2003-10-07 | — | — | US | disclosed |
| EP-1157008-A1 | QUINOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | AstraZeneca AB (SE) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000050405-A1 | QUINOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2000-08-31 | — | — | WO | disclosed |