Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 6/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.47 |
| ▸ | FABP3 | P05413 | 2/20 | 0.41 |
| ▸ | FABP4 | P15090 | 2/20 | 0.41 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | HTR2B | P41595 | 2/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28324731 | 0.78 | PTGS1 (0.42) | GABRA1GABRB2CA1CA2LMNA | |
| SCHEMBL28207929 | 0.76 | GABRA1 (0.39) | GABRA1GABRB2FABP3FABP4FABP5 | |
| SCHEMBL5095128 | 0.76 | GABRA1 (0.39) | GABRA1GABRB2FABP3FABP4FABP5 | |
| SCHEMBL94533 | 0.69 | GABRA1 (0.77) | GABRA1GABRB2FABP3FABP4FABP5 | |
| SCHEMBL3602717 | 0.68 | TYR (0.40) | GABRA1GABRB2CA1CA2GABRB1 | |
| Ammonia Solution, Strong SCHEMBL28098766 | 0.67 | GABRA1 (0.74) | GABRA1GABRB2FABP3FABP4FABP5 | |
| SCHEMBL28199640 | 0.66 | GABRA1 (0.32) | GABRA1GABRB2FABP3FABP4FABP5 | |
| SCHEMBL224395 | 0.64 | ALOX12 (0.59) | GABRA1GABRB2FABP3FABP4FABP5 | |
| SCHEMBL8649694 | 0.64 | LMNA (0.37) | LMNAPTGS1TRPA1CACNA1C | |
| SCHEMBL16957307 | 0.64 | GABRA1 (0.35) | GABRA1GABRB2FABP3FABP4CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6534518-B1 | Phosphodiesterase inhibitors for respiratory system disorders | ALTANA PHARMA AG (DE) | 2003-03-18 | — | — | US | disclosed |
| EP-1163226-A1 | POLYSUBSTITUTED 6-PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000042018-A1 | POLYSUBSTITUTED 6-PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2000-07-20 | — | — | WO | disclosed |