Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | SPR | P35270 | 1/20 | 0.42 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | ALKBH1 | Q13686 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7240740 | 0.80 | MAPK1 (0.50) | MAPK1SMN1; SMN2MAOBSPRKDM5A | |
| SCHEMBL7239669 | 0.74 | NPC1 (0.49) | MAPK1SMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL8669437 | 0.72 | ALDH1A1 (0.55) | MAPK1SMN1; SMN2MAOBNPC1RAB9A | |
| SCHEMBL31069949 | 0.71 | MCL1 (0.50) | KDM5AKDM4CHPGDCYP2C9 | |
| SCHEMBL7236175 | 0.70 | MAPT (0.52) | SMN1; SMN2HPGDNPC1RAB9AMAPT | |
| SCHEMBL1574919 | 0.69 | MAPK1 (0.63) | MAPK1SMN1; SMN2SPRKDM5AKDM4C | |
| SCHEMBL18689771 | 0.69 | KMT2A (0.44) | MAPK1SMN1; SMN2SPRHPGDNPC1 | |
| SCHEMBL2544046 | 0.68 | MAPK1 (1.00) | MAPK1SMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL906012 | 0.68 | HTR6 (0.51) | POLBCYP2C19 | |
| SCHEMBL17454421 | 0.68 | TDP1 (0.54) | MAPK1SMN1; SMN2MAOBALKBH1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6552018-B1 | As antitumor agents | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2003-04-22 | — | — | US | disclosed |
| CN-1105707-C | Pyrazole derivative | DAIICHI SEIYAKU CO (JP) | 2003-04-16 | — | — | CN | disclosed |
| US-6169086-B1 | AN ANTITUMOR AGENT FOR TREATING TUMOR RESISTANT TO 5-FLUOROURACIL TYPE DRUGS | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2001-01-02 | — | — | US | disclosed |
| EP-1022270-A1 | PYRAZOLE DERIVATIVES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2000-07-26 | — | — | EP | disclosed |
| CN-1251578-A | Pyrazole derivative | DAIICHI SEIYAKU CO (JP) | 2000-04-26 | — | — | CN | disclosed |