SCHEMBL722955

SCHEMBL722955

NC(=O)OC(Cl)c1ccccc1Cl

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 2/20 0.41
TDO2 P48775 2/20 0.41
IDO2 Q6ZQW0 2/20 0.41
OPRM1 P35372 2/20 0.39
OPRL1 P41146 2/20 0.39
CYP2C9 P11712 2/20 0.39
OPRD1 P41143 1/20 0.39
OPRK1 P41145 1/20 0.39
CXCL8 P10145 1/20 0.39
CASP1 P29466 1/20 0.39
KMT2A Q03164 2/20 0.39
CYP3A4 P08684 2/20 0.39
ACP3 P15309 1/20 0.39
MEN1 O00255 1/20 0.39
CYP1A2 P05177 1/20 0.39
ATM Q13315 2/20 0.38
AOC3 Q16853 1/20 0.38
TSHR P16473 2/20 0.37
HIF1A Q16665 2/20 0.37
KDM4E B2RXH2 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2345812 0.83 ACP3 (0.43) IDO1TDO2IDO2OPRM1OPRL1
SCHEMBL10876491 0.83 CASP1 (0.40) IDO1TDO2IDO2OPRM1OPRL1
SCHEMBL14790118 0.80 LPAR1 (0.45) IDO1TDO2IDO2CXCL8CASP1
SCHEMBL514180 0.80 LPAR1 (0.45) IDO1TDO2IDO2CXCL8CASP1
SCHEMBL4607561 0.80 ACP3 (0.41) IDO1TDO2IDO2OPRM1OPRL1
SCHEMBL255995 0.77 NISCH (0.44) IDO1TDO2IDO2CXCL8CASP1
SCHEMBL3815968 0.77 CASP1 (0.39) IDO1TDO2IDO2CXCL8CASP1
SCHEMBL10894345 0.77 CASP1 (0.39) CXCL8CASP1ACP3TSHRLMNA
SCHEMBL10119442 0.76 CXCL8 (0.41) IDO1TDO2IDO2CXCL8CASP1
SCHEMBL11167494 0.76 CASP1 (0.48) OPRM1OPRL1CASP1ACP3AOC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023168066-A9 OXIME-BASED HOT MELT ADHESIVES FOR REWORK, REPAIR AND RECYCLE CONAGEN INC. (US) 2024-06-20 WO disclosed
WO-2023168066-A1 OXIME-BASED HOT MELT ADHESIVES FOR REWORK, REPAIR AND RECYCLE CONAGEN INC. (US) 2023-09-07 WO disclosed
EP-3737362-A1 COMBINATION OF A SELECTIVE HISTONE DEACETYLASE 3 (HDAC3) INHIBITOR AND AN IMMUNOTHERAPY AGENT FOR THE TREATMENT OF CANCER KDAC THERAPEUTICS, INC. (US) 2020-11-18 EP disclosed
WO-2017190061-A1 SYNTHETIC DNA BINDING DOMAIN PEPTIDES AND USES THEREOF THE UNIVERSITY OF CHICAGO (US) 2017-11-02 WO disclosed
WO-2012027555-A2 GLYCATED CD59 PEPTIDES, THEIR PREPARATION, AND USES THEREOF PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2012-03-01 WO disclosed
EP-2367798-A2 TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS Cambria Pharmaceuticals, Inc. (US) 2011-09-28 EP disclosed
EP-2331018-A1 ESOPHAGEAL VALVE Vysera Biomedical Limited (IE) 2011-06-15 EP disclosed
EP-2303888-A2 METHODS AND COMPOUNDS FOR ANTIMICROBIAL INTERVENTION President and Fellows of Harvard College (US) 2011-04-06 EP disclosed
WO-2010059241-A2 TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS CAMBRIA PHARMACEUTICALS, INC. (US) 2010-05-27 WO disclosed
WO-2009153770-A1 ESOPHAGEAL VALVE VYSERA BIOMEDICAL LIMITED (IE) 2009-12-23 WO disclosed
WO-2009151561-A2 METHODS AND COMPOUNDS FOR ANTIMICROBIAL INTERVENTION PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2009-12-17 WO disclosed