Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 6/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7221029 | 0.86 | CHRNB2 (0.36) | CYP11B1CYP11B2OPRL1CHRNB2CHRNA4 | |
| SCHEMBL7971885 | 0.85 | KMT2A (0.34) | KMT2ACYP11B1CYP11B2OPRL1CHRNB2 | |
| SCHEMBL16139986 | 0.83 | OPRL1 (0.36) | OPRL1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL7227978 | 0.83 | CHRNB2 (0.34) | CYP11B1CYP11B2OPRL1CHRNB2CHRNA4 | |
| SCHEMBL7223956 | 0.82 | OPRL1 (0.36) | CYP11B1CYP11B2OPRL1BACE1BACE2 | |
| SCHEMBL7223397 | 0.82 | OPRL1 (0.36) | CYP11B2OPRL1 | |
| SCHEMBL6617335 | 0.82 | OPRL1 (0.41) | CYP11B1CYP11B2OPRL1CHRNB2CHRNA4 | |
| SCHEMBL7222900 | 0.82 | OPRL1 (0.36) | OPRL1CHRNB2CHRNA4 | |
| SCHEMBL7223737 | 0.82 | OPRL1 (0.36) | CYP11B2OPRL1CHRNB2CHRNA4KDM4E | |
| SCHEMBL7228554 | 0.82 | CHRNB2 (0.43) | OPRL1CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6573275-B1 | Insecticidal compositions comprising and to methods of combatting and controlling insect pests therewith. | SYNGENTA LIMITED (GB) | 2003-06-03 | — | — | US | disclosed |
| EP-0828739-B1 | BICYCLIC AMINES AS INSECTICIDES | SYNGENTA LTD (GB) | 2002-09-11 | — | — | EP | disclosed |
| US-6207676-B1 | Bicyclic amines | ZENECA LIMITED (GB) | 2001-03-27 | — | — | US | disclosed |