Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 5/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | PLEC | Q15149 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | KDM6B | O15054 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7229971 | 0.93 | HCAR3 (0.45) | HCAR3GAAKDM4EALDH1A1HPGD | |
| SCHEMBL7232819 | 0.92 | HCAR3 (0.44) | HCAR3KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL7240516 | 0.92 | HCAR3 (0.44) | HCAR3KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL7240060 | 0.85 | GAA (0.35) | GAAKDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL7229705 | 0.85 | MAPT (0.41) | GAAKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL7240509 | 0.84 | HCAR3 (0.35) | HCAR3GAAKDM4EALDH1A1HPGD | |
| SCHEMBL30249775 | 0.84 | HCAR3 (0.43) | HCAR3GAAKDM4EALDH1A1HPGD | |
| SCHEMBL7229957 | 0.84 | HCAR3 (0.43) | HCAR3GAAKDM4EALDH1A1HPGD | |
| SCHEMBL7230157 | 0.83 | MGLL (0.40) | HCAR3GAAKDM4EALDH1A1HPGD | |
| SCHEMBL7233569 | 0.83 | HCAR3 (0.38) | HCAR3GAAPTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6509359-B1 | Use as a neuramninidase inhibitor in virus | BIOCRYST PHARMACEUTICALS, INC. | 2003-01-21 | — | — | US | claimed |
| WO-1999014191-A1 | PYRROLIDIN-2-ONE COMPOUNDS AND THEIR USE AS NEURAMINIDASE INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 1999-03-25 | — | — | WO | claimed |
| US-6509359-B1 | Use as a neuramninidase inhibitor in virus | BIOCRYST PHARMACEUTICALS, INC. | 2003-01-21 | — | — | US | disclosed |
| WO-1999014191-A1 | PYRROLIDIN-2-ONE COMPOUNDS AND THEIR USE AS NEURAMINIDASE INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 1999-03-25 | — | — | WO | disclosed |