Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 17/20 | 0.65 |
| ▸ | MMP9 | P14780 | 17/20 | 0.65 |
| ▸ | MMP1 | P03956 | 6/20 | 0.65 |
| ▸ | MMP3 | P08254 | 5/20 | 0.65 |
| ▸ | MMP13 | P45452 | 3/20 | 0.65 |
| ▸ | MMP14 | P50281 | 3/20 | 0.56 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.56 |
| ▸ | MMP8 | P22894 | 3/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7226591 | 0.89 | MMP2 (0.60) | MMP2MMP9MMP1MMP3MMP13 | |
| SCHEMBL7223370 | 0.86 | MMP2 (0.56) | MMP2MMP9MMP1MMP3MMP13 | |
| SCHEMBL6580404 | 0.83 | MMP2 (0.67) | MMP2MMP9MMP1MMP3MMP13 | |
| SCHEMBL7230732 | 0.79 | MMP2 (0.66) | MMP2MMP9MMP1MMP3MMP13 | |
| SCHEMBL7222497 | 0.77 | MMP2 (0.64) | MMP2MMP9MMP1MMP3MMP13 | |
| SCHEMBL7077886 | 0.76 | MMP2 (0.66) | MMP2MMP9MMP1MMP3MMP13 | |
| SCHEMBL7224858 | 0.75 | MMP2 (0.70) | MMP2MMP9MMP1MMP3MMP13 | |
| SCHEMBL7945656 | 0.75 | MMP2 (0.77) | MMP2MMP9MMP1MMP3MMP13 | |
| SCHEMBL7224278 | 0.75 | MMP2 (0.61) | MMP2MMP9MMP1MMP3MMP13 | |
| SCHEMBL6383136 | 0.73 | MMP2 (0.60) | MMP2MMP9MMP1MMP3MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6605604-B1 | Tumour necrosis factor alpha release inhibitors; efficiency treatment of cancers, rheumatic diseases, arthritis, ulcers, atherosclerosis, asthma | LES LABORATOIRES SERVIER (FR) | 2003-08-12 | — | — | US | disclosed |