SCHEMBL6383136

SCHEMBL6383136

O=C(NO)C(CS(=O)(=O)c1ccccc1)CS(=O)(=O)c1ccccc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 6/20 0.60
MMP9 P14780 6/20 0.60
MMP8 P22894 5/20 0.60
MMP1 P03956 6/20 0.58
MMP3 P08254 5/20 0.58
MMP13 P45452 12/20 0.55
HDAC3 O15379 1/20 0.47
HDAC4 P56524 1/20 0.47
HDAC1 Q13547 1/20 0.47
HDAC7 Q8WUI4 1/20 0.47
HDAC2 Q92769 1/20 0.47
HDAC10 Q969S8 1/20 0.47
HDAC11 Q96DB2 1/20 0.47
HDAC8 Q9BY41 1/20 0.47
HDAC6 Q9UBN7 1/20 0.47
HDAC9 Q9UKV0 1/20 0.47
HDAC5 Q9UQL6 1/20 0.47
MMP7 P09237 1/20 0.46
MMP14 P50281 1/20 0.46
HSD11B1 P28845 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7366507 0.84 MMP2 (0.52) MMP2MMP9MMP8MMP1MMP3
SCHEMBL7363878 0.84 MMP9 (0.62) MMP2MMP9MMP8MMP1MMP3
SCHEMBL7365162 0.83 MMP2 (0.51) MMP2MMP9MMP8MMP1MMP3
SCHEMBL6378624 0.83 MMP13 (0.53) MMP2MMP9MMP8MMP1MMP3
SCHEMBL17697191 0.81 MMP2 (0.54) MMP2MMP9MMP8MMP1MMP3
SCHEMBL6378620 0.79 MMP1 (0.58) MMP2MMP9MMP8MMP1MMP13
SCHEMBL7300411 0.77 MMP1 (0.67) MMP2MMP9MMP8MMP1MMP3
SCHEMBL6764610 0.76 MMP13 (0.70) MMP2MMP9MMP1MMP3MMP13
SCHEMBL7492579 0.76 HSD11B1 (0.49) MMP2MMP9MMP8MMP1MMP3
SCHEMBL7492571 0.76 HSD11B1 (0.49) MMP2MMP9MMP8MMP1MMP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0929519-A1 $g(b)-SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASES INHIBITORS PHARMACIA & UPJOHN COMPANY (US) 1999-07-21 EP claimed
WO-1998013340-A1 β-SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASES INHIBITORS PHARMACIA & UPJOHN COMPANY (US) 1998-04-02 WO claimed
EP-0929519-B1 BETA-SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASES INHIBITORS UPJOHN CO (US) 2005-02-23 EP disclosed
US-6235928-B1 ENZYME INHIBITOR MATRIX METALLOPROTEINASE FAMILY, INCLUDING COLLAGENASE, STROMELYSIN, AND GELATINASE, THE COMPOUNDS OR PHARMACEUTICAL COMPOSITIONS PHARMACIA & UPJOHN COMPANY 2001-05-22 US disclosed
EP-0929519-A1 $g(b)-SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASES INHIBITORS PHARMACIA & UPJOHN COMPANY (US) 1999-07-21 EP disclosed
US-5847153-A β-sulfonyl hydroxamic acids PHARMACIA & UPJOHN COMPANY (US) 1998-12-08 US disclosed
WO-1998013340-A1 β-SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASES INHIBITORS PHARMACIA & UPJOHN COMPANY (US) 1998-04-02 WO disclosed