Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | CTSC | P53634 | 1/20 | 0.40 |
| ▸ | TEC | P42680 | 1/20 | 0.39 |
| ▸ | TXK | P42681 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | ITK | Q08881 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 8/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.37 |
| ▸ | HTR3B | O95264 | 4/20 | 0.37 |
| ▸ | HTR3A | P46098 | 4/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.37 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7230436 | 0.87 | CTSS (0.42) | CTSSCTSKTECTXKBTK | |
| SCHEMBL7224866 | 0.87 | CTSC (0.40) | CTSCTECTXKBTKITK | |
| SCHEMBL7224824 | 0.85 | CHRNA7 (0.38) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7223916 | 0.84 | CTSC (0.35) | CTSSCTSKCTSCEGLN1 | |
| SCHEMBL7232573 | 0.83 | CTSC (0.34) | CTSCEGLN1 | |
| SCHEMBL7224193 | 0.83 | HDAC3 (0.53) | CTSSCTSKCHRNA7HTR3EHTR3B | |
| SCHEMBL7232229 | 0.83 | HDAC6 (0.50) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7224860 | 0.82 | KDM4E (0.55) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7226599 | 0.82 | KDM4E (0.37) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7233013 | 0.81 | RXFP1 (0.47) | CHRNA7HTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |