Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 13/20 | 1.00 |
| ▸ | MMP2 | P08253 | 12/20 | 1.00 |
| ▸ | MMP9 | P14780 | 11/20 | 1.00 |
| ▸ | MMP13 | P45452 | 11/20 | 1.00 |
| ▸ | MMP1 | P03956 | 6/20 | 0.70 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | MITF | O75030 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | MME | P08473 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7232475 | 0.90 | MMP2 (0.82) | MMP3MMP2MMP9MMP13MMP1 | |
| SCHEMBL7223434 | 0.83 | MMP2 (1.00) | MMP3MMP2MMP9MMP13MMP1 | |
| SCHEMBL7222078 | 0.77 | MMP2 (1.00) | MMP3MMP2MMP9MMP13MMP1 | |
| SCHEMBL7223589 | 0.75 | MMP2 (1.00) | MMP3MMP2MMP9MMP13MMP1 | |
| SCHEMBL7230994 | 0.75 | MMP2 (1.00) | MMP3MMP2MMP9MMP13MMP1 | |
| SCHEMBL7224527 | 0.74 | MMP2 (0.84) | MMP3MMP2MMP9MMP13MMP1 | |
| SCHEMBL7233440 | 0.73 | MMP2 (0.81) | MMP3MMP2MMP9MMP13MMP1 | |
| SCHEMBL15733161 | 0.73 | MMP2 (0.57) | MMP3MMP2MMP9MMP13MMP1 | |
| SCHEMBL7223278 | 0.72 | MMP2 (0.82) | MMP3MMP2MMP9MMP13MMP1 | |
| SCHEMBL7230599 | 0.72 | MMP2 (1.00) | MMP3MMP2MMP9MMP13MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6605604-B1 | Tumour necrosis factor alpha release inhibitors; efficiency treatment of cancers, rheumatic diseases, arthritis, ulcers, atherosclerosis, asthma | LES LABORATOIRES SERVIER (FR) | 2003-08-12 | — | — | US | disclosed |
| EP-1091937-A1 | CARBOXYLIC AND HYDROXAMIC ACID COMPOUNDS INHIBITING METALLOPROTEASES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ADIR ET COMPAGNIE (FR) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000000473-A1 | CARBOXYLIC AND HYDROXAMIC ACID COMPOUNDS INHIBITING METALLOPROTEASES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ADIR ET COMPAGNIE (FR) | 2000-01-06 | — | — | WO | disclosed |