Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 9/20 | 1.00 |
| ▸ | MMP3 | P08254 | 9/20 | 1.00 |
| ▸ | MMP9 | P14780 | 9/20 | 1.00 |
| ▸ | MMP13 | P45452 | 9/20 | 1.00 |
| ▸ | MMP1 | P03956 | 5/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7234127 | 0.90 | MMP2 (0.82) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7223434 | 0.77 | MMP2 (1.00) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7231815 | 0.75 | MMP3 (1.00) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7230599 | 0.72 | MMP2 (1.00) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7222078 | 0.71 | MMP2 (1.00) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7224224 | 0.70 | MMP2 (1.00) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7224527 | 0.70 | MMP2 (0.84) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL379356 | 0.69 | MMP1 (0.53) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL7233440 | 0.69 | MMP2 (0.81) | MMP2MMP3MMP9MMP13MMP1 | |
| SCHEMBL6723991 | 0.69 | MMP2 (0.56) | MMP2MMP3MMP9MMP13MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6605604-B1 | Tumour necrosis factor alpha release inhibitors; efficiency treatment of cancers, rheumatic diseases, arthritis, ulcers, atherosclerosis, asthma | LES LABORATOIRES SERVIER (FR) | 2003-08-12 | — | — | US | disclosed |