Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 13/20 | 1.00 |
| ▸ | MMP9 | P14780 | 13/20 | 1.00 |
| ▸ | MMP3 | P08254 | 10/20 | 1.00 |
| ▸ | MMP13 | P45452 | 10/20 | 1.00 |
| ▸ | MMP1 | P03956 | 7/20 | 0.88 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.53 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MMP14 | P50281 | 2/20 | 0.46 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7225679 | 0.89 | MMP2 (0.80) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL7233440 | 0.84 | MMP2 (0.81) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL7230149 | 0.83 | MMP2 (0.70) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL7229104 | 0.82 | MMP2 (0.79) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL7224224 | 0.79 | MMP2 (1.00) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL7224858 | 0.77 | MMP2 (0.70) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL10674350 | 0.76 | RAB9A (0.82) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL7224271 | 0.75 | MMP2 (0.67) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL8483472 | 0.74 | RAB9A (0.74) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL7222497 | 0.74 | MMP2 (0.64) | MMP2MMP9MMP3MMP13MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6605604-B1 | Tumour necrosis factor alpha release inhibitors; efficiency treatment of cancers, rheumatic diseases, arthritis, ulcers, atherosclerosis, asthma | LES LABORATOIRES SERVIER (FR) | 2003-08-12 | — | — | US | disclosed |
| EP-1091937-A1 | CARBOXYLIC AND HYDROXAMIC ACID COMPOUNDS INHIBITING METALLOPROTEASES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ADIR ET COMPAGNIE (FR) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000000473-A1 | CARBOXYLIC AND HYDROXAMIC ACID COMPOUNDS INHIBITING METALLOPROTEASES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ADIR ET COMPAGNIE (FR) | 2000-01-06 | — | — | WO | disclosed |