Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.51 |
| ▸ | FYN | P06241 | 5/20 | 0.46 |
| ▸ | SRC | P12931 | 5/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7245075 | 0.86 | EGFR (0.55) | EGFRERBB2 | |
| SCHEMBL8308341 | 0.82 | IGF1R (0.50) | EGFR | |
| SCHEMBL8490631 | 0.80 | EGFR (0.55) | EGFRERBB2FYNSRC | |
| Hydrochloric Acid SCHEMBL8310540 | 0.80 | EGFR (0.50) | EGFRERBB2LCK | |
| SCHEMBL8309667 | 0.76 | IGF1R (0.67) | EGFRERBB2 | |
| SCHEMBL2200467 | 0.76 | IGF1R (0.67) | EGFRERBB2 | |
| Hydrochloric Acid SCHEMBL8304910 | 0.75 | IGF1R (0.66) | EGFRERBB2LCK | |
| SCHEMBL7243799 | 0.73 | EGFR (0.64) | EGFRERBB2FYNSRC | |
| SCHEMBL7235777 | 0.72 | EGFR (0.62) | EGFRERBB2FYNSRC | |
| SCHEMBL7235776 | 0.72 | EGFR (0.62) | EGFRERBB2FYNSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127374-A | AN ENZYME INHIBITOR FOR TREATING CANCER, RESTENOSIS, ATHEROSCLEROSIS, ENDOMETRIOSIS AND PSORIASIS | WARNER-LAMBERT COMPANY (US) | 2000-10-03 | — | — | US | claimed |
| WO-1999006378-A1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | claimed |
| US-6562818-B1 | For treating cancer, atherosclerosis, restenosis, endometriosis, and psoriasis | WARNER-LAMBERT COMPANY | 2003-05-13 | — | — | US | disclosed |
| US-6127374-A | AN ENZYME INHIBITOR FOR TREATING CANCER, RESTENOSIS, ATHEROSCLEROSIS, ENDOMETRIOSIS AND PSORIASIS | WARNER-LAMBERT COMPANY (US) | 2000-10-03 | — | — | US | disclosed |
| WO-1999006378-A1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |