SCHEMBL7233161

SCHEMBL7233161

N#Cc1cccc(C(=O)NCc2ccc(Br)cc2)c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM3 P20309 1/20 0.54
HDAC6 Q9UBN7 2/20 0.52
HDAC2 Q92769 1/20 0.52
HDAC8 Q9BY41 1/20 0.52
GSK3B P49841 2/20 0.51
GAA P10253 1/20 0.51
EPHX2 P34913 2/20 0.50
MAOA P21397 1/20 0.48
GPR139 Q6DWJ6 1/20 0.48
NR1H4 Q96RI1 1/20 0.48
CA1 P00915 1/20 0.48
CA2 P00918 1/20 0.48
HDAC1 Q13547 1/20 0.48
ROCK2 O75116 1/20 0.47
VNN1 O95497 3/20 0.47
SENP1 Q9P0U3 1/20 0.47
NAMPT P43490 1/20 0.47
SMPD1 P17405 1/20 0.47
LMNA P02545 1/20 0.47
HPGD P15428 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17142140 0.87 HDAC2 (0.64) CHRM3HDAC6HDAC2HDAC8GAA
SCHEMBL15606157 0.86 EPHX2 (0.56) HDAC6HDAC2HDAC8EPHX2MAOA
SCHEMBL5091359 0.86 CHRM3 (0.54) CHRM3HDAC6HDAC2HDAC8GSK3B
SCHEMBL7985996 0.85 GAA (0.56) CHRM3GAAVNN1SMPD1
SCHEMBL7989764 0.85 GAA (0.53) CHRM3HDAC6HDAC2HDAC8GSK3B
SCHEMBL28146231 0.85 CHRM3 (0.55) CHRM3HDAC6HDAC2HDAC8GSK3B
SCHEMBL7986109 0.84 MAOB (0.55) CHRM3GAAVNN1SMPD1LMNA
SCHEMBL17339504 0.84 TRPV1 (0.55) CHRM3HDAC6HDAC2HDAC8GSK3B
SCHEMBL29617710 0.84 TRPV1 (0.55) CHRM3HDAC6HDAC2HDAC8GSK3B
SCHEMBL7972494 0.84 MAOB (0.55) CHRM3GAAVNN1NAMPTSMPD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6548512-B1 Pyrazole derivatives such as 1-(3-amidinophenyl)-3-methyl-2-((5-(2'-aminosulfonylphenyl-1-yl)pyrimidin-2 -yl)aminocarbonyl)pyrazole; treating thromboembolic disorders BRISTOL-MYERS SQUIBB PHARMA COMPANY 2003-04-15 US disclosed
US-6020357-A CARDIOVASCULAR DISORDERS; ANTCOAGULANTS DUPONT PHARMACEUTICALS COMPANY (US) 2000-02-01 US disclosed
EP-0946508-A1 NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS Du Pont Pharmaceuticals Company (US) 1999-10-06 EP disclosed
WO-1998028269-A1 NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS DU PONT PHARMACEUTICALS COMPANY (US) 1998-07-02 WO disclosed