Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | DPP4 | P27487 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29395449 | 0.89 | POLB (0.63) | GAACYP1A2POLBDPP4ALDH1A1 | |
| SCHEMBL7994938 | 0.87 | POLB (0.62) | GAACYP1A2POLBDPP4ALDH1A1 | |
| SCHEMBL6697154 | 0.85 | ALDH1A1 (0.63) | GAACYP1A2POLBDPP4ALDH1A1 | |
| SCHEMBL13649701 | 0.82 | SMN1; SMN2 (0.58) | GAACYP1A2POLBDPP4ALDH1A1 | |
| SCHEMBL13947445 | 0.82 | POLB (0.60) | GAACYP1A2POLBDPP4ALDH1A1 | |
| SCHEMBL5091559 | 0.82 | POLB (0.60) | GAACYP1A2POLBDPP4ALDH1A1 | |
| SCHEMBL8365566 | 0.81 | DPP4 (0.58) | GAACYP1A2POLBDPP4ALDH1A1 | |
| SCHEMBL5650522 | 0.81 | SMN1; SMN2 (0.60) | GAACYP1A2POLBDPP4ALDH1A1 | |
| SCHEMBL5100760 | 0.81 | SMN1; SMN2 (0.60) | GAACYP1A2POLBDPP4ALDH1A1 | |
| SCHEMBL4389868 | 0.80 | SMN1; SMN2 (0.59) | GAACYP1A2POLBDPP4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6599908-B1 | Potent and selective inhibitors of the protein tyrosine kinases p56lck and p59fyn | CELLTECH R & D LIMITED (GB) | 2003-07-29 | — | — | US | disclosed |
| US-6057329-A | Fused polycyclic 2-aminopyrimidine derivatives | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-05-02 | — | — | US | disclosed |
| EP-0946523-A1 | FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PROTEIN TYROSINE KINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998028281-A1 | FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PROTEIN TYROSINE KINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-07-02 | — | — | WO | disclosed |