Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 5/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 12/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 5/20 | 0.34 |
| ▸ | HTR3B | O95264 | 5/20 | 0.34 |
| ▸ | HTR3A | P46098 | 5/20 | 0.34 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 0.34 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.33 |
| ▸ | CHRNG | P07510 | 1/20 | 0.33 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CHRND | Q07001 | 1/20 | 0.33 |
| ▸ | CHRNA2 | Q15822 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7225477 | 0.88 | CHRNA7 (0.36) | AKT1CHRNA7HTR3EHTR3BHTR3A | |
| SCHEMBL7232339 | 0.85 | CHRNA7 (0.36) | AKT1CHRNA7HTR3EHTR3BHTR3A | |
| SCHEMBL7231059 | 0.85 | ALDH1A1 (0.38) | AKT1CHRNA7HTR3EHTR3BHTR3A | |
| SCHEMBL7230457 | 0.85 | CHRNA7 (0.37) | AKT1CHRNA7HTR3EHTR3BHTR3A | |
| SCHEMBL7231089 | 0.85 | CHRNA7 (0.37) | AKT1CHRNA7HTR3EHTR3BHTR3A | |
| SCHEMBL7225620 | 0.84 | AKT1 (0.37) | AKT1CHRNA7HTR3EHTR3BHTR3A | |
| SCHEMBL7223964 | 0.82 | CHRNA7 (0.42) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7243634 | 0.82 | CHRNA7 (0.42) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7243631 | 0.82 | CHRNA7 (0.42) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7224923 | 0.82 | AKT1 (0.36) | AKT1CHRNA7HTR3EHTR3BHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |