Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 8/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 5/20 | 0.34 |
| ▸ | HTR3B | O95264 | 5/20 | 0.34 |
| ▸ | HTR3A | P46098 | 5/20 | 0.34 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 0.34 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 0.34 |
| ▸ | AKT1 | P31749 | 7/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7233242 | 0.88 | AKT1 (0.36) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7232339 | 0.87 | CHRNA7 (0.36) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7233692 | 0.85 | TXK (0.36) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7233633 | 0.84 | ITK (0.39) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7224299 | 0.83 | NPC1 (0.45) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7224289 | 0.82 | CHRNA7 (0.36) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7232814 | 0.82 | CHRNA7 (0.37) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7226198 | 0.82 | CHRNA7 (0.34) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7227405 | 0.82 | MAPK13 (0.50) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7232306 | 0.82 | CHRNA7 (0.39) | CHRNA7HTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |