Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 10/20 | 0.37 |
| ▸ | AKT1 | P31749 | 3/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 5/20 | 0.35 |
| ▸ | HTR3B | O95264 | 5/20 | 0.35 |
| ▸ | HTR3A | P46098 | 5/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 0.35 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESRRG | P62508 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7224289 | 0.87 | CHRNA7 (0.36) | CHRNA7AKT1HTR3EHTR3BHTR3A | |
| SCHEMBL7233242 | 0.85 | AKT1 (0.36) | CHRNA7AKT1HTR3EHTR3BHTR3A | |
| SCHEMBL7225620 | 0.85 | AKT1 (0.37) | CHRNA7AKT1HTR3EHTR3BHTR3A | |
| SCHEMBL7232161 | 0.85 | CHRNA7 (0.38) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7224322 | 0.83 | CHRNA7 (0.40) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7223682 | 0.82 | AKT1 (0.40) | CHRNA7AKT1HTR3EHTR3BHTR3A | |
| SCHEMBL7231972 | 0.81 | ESRRG (0.46) | CHRNA7AKT1HTR3EHTR3BHTR3A | |
| SCHEMBL7231059 | 0.81 | ALDH1A1 (0.38) | CHRNA7AKT1HTR3EHTR3BHTR3A | |
| SCHEMBL7231089 | 0.81 | CHRNA7 (0.37) | CHRNA7AKT1HTR3EHTR3BHTR3A | |
| SCHEMBL7224677 | 0.81 | MEN1 (0.43) | RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |