Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.43 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | LYN | P07948 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | PRKCI | P41743 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAP3K10 | Q02779 | 1/20 | 0.43 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.43 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6646514 | 0.80 | MAPK14 (0.56) | MAPK14MAPK9MAPK13CSNK1DMAPK10 | |
| SCHEMBL6933665 | 0.78 | MAPK14 (0.50) | MAPK14MAPK9MAPK13CSNK1DMAPK10 | |
| SCHEMBL6933664 | 0.78 | MAPK14 (0.50) | MAPK14MAPK9MAPK13CSNK1DMAPK10 | |
| SCHEMBL6646517 | 0.76 | MAPK14 (0.56) | MAPK14MAPK9MAPK13CSNK1DMAPK10 | |
| SCHEMBL6936438 | 0.75 | GSK3B (0.59) | MAPK14MAPK9MAPK13CSNK1DMAPK10 | |
| SCHEMBL7134546 | 0.75 | MAPK14 (0.65) | MAPK14MAPK9MAPK13CSNK1DMAPK10 | |
| SCHEMBL6932108 | 0.75 | MAPK14 (0.52) | MAPK14MAPK9MAPK13CSNK1DMAPK10 | |
| SCHEMBL6934767 | 0.75 | MAPK14 (0.57) | MAPK14MAPK9MAPK13CSNK1DMAPK10 | |
| SCHEMBL6934712 | 0.74 | MAPK14 (0.47) | MAPK14MAPK9MAPK13CSNK1DMAPK10 | |
| SCHEMBL7240785 | 0.74 | MAPK14 (0.50) | MAPK14MAPK9MAPK13CSNK1DMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030073704-A1 | Substituted pyridone compounds and methods of use | AMGEN INC. | 2003-04-17 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030073704-A1 | Substituted pyridone compounds and methods of use | IL6, IL1B, IL1A | MAPK14 1169/4885MAPKAPK2 1161/4885MAPK9 1247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.